Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood

In 2007, a multifaceted syndrome, associated with anti-NMDA receptor autoantibodies (NMDAR-AB) of immunoglobulin-G isotype,has been described, which variably consists of psychosis, epilepsy,cognitive decline and extrapyramidal symptoms. Prevalence and significance of NMDAR-AB in complex neuropsychiatric disease versus health, however, have remained unclear. We tested sera of 2817 subjects (1325 healthy, 1081 schizophrenic, 263 Parkinson and 148 affective-disorder subjects) for presence of NMDAR-AB,conducted a genome-wide genetic association study, comparing AB carriers versus non-carriers, and assessed their influenza AB status.