IgA NMDA receptor antibodies are markers of synaptic immunity in slow cognitive impairment

Objective: To report that antibodies to synaptic proteins may occur in association with slow, progressive cognitive decline.
Methods: A total of 24 patients with progressive cognitive dysfunction of unclear etiology wereexamined for onconeuronal and synaptic receptor antibodies. The effect of serum was examined in cultures of dissociated mouse hippocampal neurons.